NRx Pharmaceuticals, Inc. (NRXP-NASDAQ)

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NRx Pharmaceuticals, Inc.
1201 N Orange St., Suite 600
Wilmington, DE 19801
Phone: (484) 254-6134 

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NRx Pharmaceuticals, Inc. (“NRx” or “the Company”) is a clinical stage biopharmaceutical company developing novel therapeutics for the treatment of central nervous system disorders with high unmet medical needs. The Company’s foundation product is NRX-101, a patented combination of two FDA-approved drugs—D-cycloserine (DCS), an NMDA receptor modulator; and lurasidone, an atypical antipsychotic medication. The Company is assessing the use of NRX-101 in four different indications: suicidal bipolar depression, chronic pain, post-traumatic stress disorder (PTSD), and complicated urinary tract infections (cUTI). Development of NMDA antagonists, such as DCS, as antidepressants has been limited by their potential psychedelic side effects. Furthermore, serotonin-targeted drugs like lurasidone have been limited by their own behavioral side effects, specifically akathisia. Professor Daniel Javitt (NRx Co-founder and Chair of its Scientific Advisory) made the simultaneous discovery that: (1) the psychedelic effects of NMDA antagonist drugs could be reversed by combining them with serotonin-targeted compounds; and (2) NMDA inhibitors, in turn, block the akathisia side effect normally associated with serotonin-targeted drugs. The previously undiscovered synergy between these two drug classes is the subject of 48 issued patents and 43 pending patents owned by or licensed to NRx Pharmaceuticals, and as such, is the medical and scientific basis for the Company’s technology platform.

* The Corporate Snapshot was last updated on December 1, 2023.

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