WABC-TV (New York) Spotlights MetaStat's Technology in 30-Minute Special

Posted by Laura Swartz

October 8, 2014 at 2:12 PM

On Sunday, October 5, 2014, an innovative molecular diagnostics technology from MetaStat, Inc. (MTST-OTC) was spotlighted in a WABC-TV news special.

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Topics: MetaStat

NEW RESEARCH: Executive Informational Overview Released for MetaStat, Inc. (MTST-OTC)

Posted by Laura Swartz

April 23, 2014 at 4:59 PM

This afternoon, we released a new Executive Informational Overview (EIO) on MetaStat, Inc. (MTST-OTC). This comprehensive, 68-page document updates an earlier EIO published on MetaStat in January 2013. The Company has achieved several significant milestones over the past year and a half, which are each detailed in the new EIO along with current product development and market descriptions for MetaStat’s diagnostic and therapeutic programs.

Company Introduction

MetaStat is a life sciences company commercializing a new approach to reliably determine a patient’s individual risk of developing systemic metastatic cancer, and then to help reduce this risk through active intervention of the metastatic process. The Company’s technology is based on a proprietary knowledge of the mechanisms that govern “metastasis” (the spread of cancer away from its primary site in the body).

The technology centers on the role of the Mena protein in tumors, and has over 15 years of study from major medical institutions including MIT, the Albert Einstein College of Medicine of Yeshiva University, Cornell University, and the IFO-Regina Elena Cancer Institute. Recent clinical studies validating MetaStat’s product candidates have also been performed by the Yale University School of Medicine, the University of Toronto, and others.

MetaStat is initially advancing two diagnostic platforms targeting breast, prostate, lung, and colorectal cancers, which could enter the market as early as 2015, as well as a therapeutic program.

  • MetaSite Breast. MetaSite Breast is a clinical laboratory assay (or test) to predict the likelihood of an early-stage breast cancer patient’s tumor spreading to distant body parts. An important distinction between MetaStat’s technology and whole genome-based assays such as Oncotype DX® and other approaches is that MetaStat focuses on predicting the risk of cancer metastasis based on the tumor’s underlying mechanisms. Historically, cancer cells have entered the blood vessels via unknown means. The research supporting the Company’s technology has sought to identify the structural and behavioral mechanisms that allow cancer cells to move and determine how this information can be used in prognosis. To MetaStat’s knowledge, its technology is the only technique to focus on such mechanistic markers. 
  • MenaCalc. The MenaCalc diagnostic technology platform is intended for use in determining individual levels of variants of the Mena protein (called “Mena isoforms”) in cancer tissue. Mena has at least five isoforms, and measuring the relationship between these variants can help create an individual metastatic profile as early on in disease progression as possible. Over time, patients’ Mena isoform profiles could identify trends and detect stability or progression of disease as well as detect the efficacy of various therapies in real time. MetaStat is developing multiple product candidates based on the MenaCalc platform to target common epithelial cancers: (1) MenaCalc Breast; (2) MenaCalc Lung; (3) MenaCalc Prostate; and (4) MenaCalc Colorectal
  • MenaBloc. As evidenced by the high mortality rate of metastatic cancers, there is an unmet medical need for therapies based on a solid understanding of the process of metastatic disease, including techniques to kill or stop the spread of metastatic cancer cells or to disrupt individual steps in the metastatic process. A MenaBloc therapeutic may ultimately prevent metastasis among high-risk patients when it is administered as a maintenance therapy after surgery or in conjunction with chemotherapy and other targeted therapies. In December 2013, MetaStat licensed a collection of alternatively spliced therapeutic targets that have a role in the epithelial to mesenchymal transition (EMT) of tumor cells. EMT is an early event in the metastatic process, which also contributes to therapeutic resistance in breast and other cancers. MetaStat believes this discovery presents a novel opportunity for new cancer therapeutics that target alternatively spliced oncogenes. 

The Company believes that its function-based diagnostics can inform better treatment decisions by identifying patients with a high risk of systemic metastasis who need aggressive therapy and sparing patients with a low risk of metastasis from painful and costly therapies. The National Institutes of Health (NIH) recently concluded that a primary goal in cancer research should be to accurately define patient risk categories with the goal of being able to administer the level of treatment needed for a successful outcome. 

Milestones and Report Topics

Click here to download and read the full Executive Informational Overview, which includes a discussion of the recent milestones listed below. 

  • Initial sales and marketing plans for MetaSite Breast, which is anticipated to commence sales in 2015
  • MetaStat’s December 2013 presentation of results from a large-scale study of its MetaSite Breast test at the San Antonio Breast Cancer Symposium
  • Results of a clinical validation of the MenaCalc technology presented at the 2014 Annual Meeting of the U.S. and Canadian Academy of Pathology
  • The October 2013 opening of a drug discovery laboratory in affiliation with Stony Brook University
  • Recent license agreements with MIT and other institutions for the use of alternatively spliced mRNA and protein isoform markers in the diagnosis, prognosis, and treatment of metastatic, epithelial-based solid tumors—which is central to the Company’s ongoing MenaBloc therapeutic development
  • Additions to executive leadership that include a former senior executive from Roche as MetaStat’s new Head of Diagnostics
  • Establishment of a highly skilled Scientific Advisory Board for Therapeutics, which includes individuals from Duke University and the Duke-NUS Medical School, the Dana-Farber Cancer Institute, the Cold Spring Harbor Laboratory, and MIT
  • Current patent position and strategies
  • Most recent historical financial position and fundraising goals

 

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Topics: MetaStat

FULL VIDEO (Reuters TV): Biotech Stocks To Watch and More

Posted by Colleen Koski

August 15, 2013 at 1:25 PM

Last week, Jeff Kraws sat down with Rhonda Schaffler at Reuters to discuss opportunities and trends in the biotech space. Mr. Kraws is a veteran Wall Street sell-side analyst with more than 20 years of experience and is also cofounder and CEO of Crystal Research Associates. If you enjoyed the short clip of this interview released earlier this week, the full segment (available below) goes into more detail on individual biotech stocks and the events every investor should be watching out for.

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Topics: AtheroNova, Crystal Research Associates, Unilife Corp., biotech, MetaStat, Reuters

MetaStat Focuses on Lead Product Opportunity and Bolstering Pipeline

Posted by Colleen Koski

April 19, 2013 at 9:13 AM

Yesterday, Crystal Research Associates published a 12-page Quarterly Update on MetaStat, Inc., a life sciences company developing next-generation diagnostic and therapeutic products for metastatic cancer. MetaStat is currently focused on three key initiatives within its pipeline: two diagnostic platforms (MetaSite™ Breast and MenaCalc™) as well as one therapeutic program (MenaBloc™). These candidates are overviewed on pages 5-8 of MetaStat's Quarterly Update.


Key Developments

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Topics: MetaStat

CEO Jeff Kraws Featured on Reuters' State of the Union Roundtable

Posted by Laura Swartz

February 13, 2013 at 3:14 PM

This morning, Crystal Research's CEO Jeff Kraws was invited to participate in a roundtable discussion to analyze how investors should be reacting to President Obama's State of the Union address. The segment was hosted by Thomson Reuters' Rhonda Schaffler and also featured David Joy, Chief Market Strategist of Ameriprise Financial, and Craig Irwin, Senior Vice President at Wedbush Securities.

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Topics: Bridgelux, Crystal Research Associates, nanotechnology, green infrastructure, Unilife Corp., MetaStat

New Research: Report on MetaStat, Inc. (MTST-OTC.BB)

Posted by Colleen Koski

January 9, 2013 at 12:23 PM

Crystal Research Associates, LLC Issues Executive Informational Overview (EIO) on
MetaStat, Inc.

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Topics: MetaStat

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