Pressure BioSciences, Inc. (PBIO-OTC), a company that develops, markets, and sells proprietary laboratory instrumentation and associated consumables to the estimated $6 billion life sciences sample preparation market, announced financial results for the three-month period and fiscal year ended December 31, 2013, and provided a business update.

This afternoon, we released a 60-page Executive Informational Overview on New Hampshire-based Boston Therapeutics, Inc. (BTHE-OTC).

Boston Therapeutics, Inc. (or “the Company”) develops products to address the diabetes and inflammatory disease markets using complex carbohydrate chemistry (CCC) technology. The Company’s portfolio includes two development-stage pharmaceutical candidates as well as a marketed over-the-counter (OTC) dietary supplement. The lead pharmaceutical candidate, BTI320 (formerly PAZ320), is a Phase II/III non-systemic, non-toxic, carbohydrate-based chewable tablet being evaluated as a therapy for Type 2 diabetes in patients currently taking metformin. The compound inhibits enzymes that release glucose from complex carbohydrates in foods during digestion—reducing the amount of glucose released from digested complex carbohydrates.

Boston Therapeutics’ second pipeline candidate is Ipoxyn™ (and a veterinary analog of Ipoxyn™, called OxyFex™), which is a carbohydrate-based intravenous solution in development to treat hypoxic conditions caused by a lack of oxygen to living tissue, such as lower-limb ischemia stemming from severe diabetes. The Ipoxyn™ molecule, which is 5,000 times smaller than a red blood cell (RBC), works by picking up oxygen in the lungs and offloading it to tissue that has been oxygen-deprived. The Company is positioned to benefit from two simultaneous paths to market—OTC and pharmaceutical drug development.

Key Points About Boston Therapeutics’ Business

• In a Phase IIa trial, BTI320 showed a 40% reduction in elevation of post-meal blood sugar with no serious adverse events. Enrollment in Phase IIb is underway, with the Company preparing for an IND filing with the FDA for a Phase III study.

Stem cell-based biotechnology company International Stem Cell Corporation (ISCO-OTC) will hold a conference call to update investors on its business and financial results on Wednesday, March 19, 2014. The call will cover results for the year ended December 31, 2013.

This morning, CardioComm Solutions, Inc. (EKG-TSX.V), a developer of software for informational management solutions used within the diagnostic cardiac and telemedicine markets, announced the receipt of an FDA Class II Medical Device Clearance for its proprietary GUAVA II ECG Viewer software.

Upon news that over the past two months, Massachusetts-based Pressure BioSciences, Inc. (PBIO-OTC) has raised an excess of $2.2 million, and seeks to raise more in February 2014, it is time to look closer at the business of this small-cap company. A quick Google search will tell you that Pressure BioSciences makes laboratory instruments for the “sample preparation” market—a market that is integral to life science research in tens of thousands of laboratories worldwide. But what is sample preparation? Is there a market for Pressure BioSciences’ products?

What is Sample Preparation?

We released a new report today--an Updated Executive Informational Overview--on AtheroNova Inc. (AHRO-OTC). AtheroNova is a clinical-stage biotechnology company focused on the research and development of bile acid therapeutic compounds to safely dissolve or regress atherosclerotic plaque and improve patients’ lipid profiles. Atherosclerotic plaque, a buildup of fat, cholesterol, and other substances in the walls of arteries, is the main underlying cause of cardiovascular disease, including heart attacks, strokes, and peripheral artery disease (PAD).

The Company’s most advanced candidate, AHRO-001, works to reduce the incidence and severity of plaque by employing a bile acid to reduce the volume of or stabilize existing plaque deposits and prevent new deposits from forming. The compound also shows significant preclinical lipid panel improvement and has beneficial effects on glucose levels involving multiple mechanisms of action.

If you missed the "Extending Life and Limb" workshop on regenerative medicine held last week at the OneMedForum conference in San Francisco, you can watch the full panel discussion on YouTube at the link below.

If you are in San Francisco today for the JP Morgan Healthcare Conference, the Biotech Showcase, or the 7th annual OneMedForum, we welcome you to stop by the Westin San Francisco on Market Street to visit our booth and hear Crystal Research CEO Jeffrey Kraws speak on regenerative medicine.

Crystal Research Associates is pleased to announce today that we have officially launched our mobile app and our new website. Take a look around at some of the changes...it is now easier than ever to sign up for research notifications and even start a discussion with us about your business's strategic needs. We have also recently expanded our line of products and services, which is now reflected throughout the site.